Introduction Inflammasomes are multi-protein complexes that play a crucial role in the innate immune system. They are responsible for the activation of inflammatory responses to pathogens and other harmful stimuli. They detect a variety of pathogens, including bacteria, viruses, and fungi, as well as stress signals like cellular damage or the presence of foreign substances.…
Read MoreEnamel matrix proteins (EMPs) play a crucial role in dental development and regeneration. are essential for the formation and development of enamel, the hard, outer surface of teeth. These proteins, primarily amelogenin, ameloblastin, and enamelin, play crucial roles in enamel biomineralization. The process of obtaining enamel matrix proteins involves several steps and methods, often depending…
Read MoreIntroduction Fibroblast growth factors (FGFs) are a family of growth factors involved in various biological processes including development, tissue repair, and metabolism. They are crucial in embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGFs are characterized by their ability to bind to heparin and heparan sulfate, which stabilizes them and enhances…
Read MoreIntroduction to piezosurgery Piezosurgery is a new technique which performs osteotomy or osteoplasty utilizing ultrasonic vibrations. It is primarily an ultrasound machine with modulated frequency and a controlled tip vibration range. It has received a wide acceptance in the medical and dental profession in a relatively shorter duration of time. It has simplified the surgical…
Read MoreIntroduction to periodontal microsurgery Periodontal microsurgery is one of the many advances that have taken place in the field of surgical periodontal therapy. Microsurgery is described as a methodology, a modification, and refinement of existing surgical techniques that uses magnification to improve visualization and has implications for and applicability to all specialities1. Historically, the first…
Read MoreIntroduction to tissue engineering Regeneration of the lost periodontal tissues is the ultimate goal of a successful periodontal therapy. A lot of techniques have been used to achieve this goal so far. More recent introduction in this context is the concept of tissue engineering. Tissue engineering is defined as the science of fabrication of new…
Read MoreIntroduction to platelet concentrates With our improved understanding regarding cellular and molecular mechanisms involved in periodontal wound healing, various regenerative techniques including, root surface biomodification, guided tissue regeneration, guided bone regeneration and application of growth factors and platelet concentrates have been introduced in periodontal regeneration. Application of platelet concentrates has been our focus of research…
Read MoreIntroduction to Bone morphogenetic proteins (BMPs): Bone morphogenetic proteins (BMPs) are composed of 400-525 amino acids. These comprise one subset of the transforming growth factor-β superfamily. They play important roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, morphogenesis, differentiation, proliferation, and apoptosis of various types of…
Read MoreIntroduction to growth factors Growth factors are polypeptide molecules released by cells in the inflamed area that regulate events in wound healing. These are naturally occurring proteins that regulate various aspects of cell growth and development, acting locally or systemically. “Growth factor” is a general term to denote a class of polypeptide hormones that stimulate…
Read MoreIntroduction to periodontal regeneration The ultimate goal of periodontal treatment is the regeneration of lost periodontal structures. Regeneration can be defined as the reproduction or reformation of organs or tissues that have been lost or injured as a result of a wound or infection. Periodontal regeneration results in functionally aligned periodontal ligament fibers between newly…
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