Introduction Arrestin beta-2 (ARRB2), one of the four members of the arrestin family, plays a pivotal role in cellular signaling, particularly in the regulation of G-protein-coupled receptors (GPCRs). Arrestins, including ARRB2, are versatile scaffold proteins that modulate various signaling pathways, influencing physiological and pathological processes. Arrestin beta-2 is a multi-domain protein consisting of approximately 410…
Read MoreIntroduction LIGHT protein (Lymphotoxin-beta receptor Interacting with G Protein-coupled Receptor), is a significant cytokine involved in immune regulation and inflammation. It plays a critical role in various physiological and pathological processes, particularly those related to immune responses and inflammation. Understanding LIGHT’s structure, function, and interactions is crucial for grasping its role in diseases, including periodontal…
Read MoreIntroduction Metabolomic analysis is a powerful tool that has gained significant attention in the study of various diseases, including periodontal disease. Periodontal disease, a chronic inflammatory condition affecting the supporting structures of the teeth, is linked to a complex interplay of microbial, host, and environmental factors. Understanding the metabolic changes associated with periodontal disease can…
Read MoreIntroduction As discussed in COVID-19 and dental practice Part-I, COVID-19, caused by the novel coronavirus SARS-CoV-2, first emerged in December 2019 in Wuhan, China. It rapidly evolved from a localized outbreak into a global pandemic, leading to unprecedented challenges for public health systems, economies, and societies worldwide. The World Health Organization (WHO) declared COVID-19 a…
Read MoreIntroduction Who does not know about COVID-19 pandemic? The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had a profound impact globally since it began in late 2019. As of now, the COVID-19 pandemic has resulted in over 6 million reported deaths worldwide. However, the World Health Organization (WHO) estimates that the actual death toll,…
Read MoreIntroduction Artificial intelligence (AI) has rapidly evolved from a concept of science fiction to a transformative force in various industries, including healthcare. Dentistry, particularly the fields of periodontics and implantology, has seen significant advancements due to the integration of AI technologies. These innovations have the potential to revolutionize diagnostic processes, treatment planning, and patient care,…
Read MoreIntroduction Botulinum toxin, commonly known as Botox, is widely recognized for its cosmetic applications in reducing facial wrinkles. However, its utility extends far beyond aesthetic enhancements. In dentistry, Botox is gaining traction for its therapeutic benefits in treating a variety of orofacial conditions. Botox is derived from the bacterium Clostridium botulinum. The Hall strain of…
Read MoreIntroduction Periodontal diseases, primarily gingivitis and periodontitis, are among the most common oral health issues globally, affecting a significant portion of the population. These conditions, characterized by inflammation and destruction of the supporting structures of teeth, can lead to tooth loss if not adequately managed. Early and accurate diagnosis is crucial for effective management and…
Read MoreIntroduction Periodontics is a branch of dentistry that focuses on the structures supporting the teeth, including the gums and bone. Traditionally, periodontal treatment has followed a one-size-fits-all approach, often leading to suboptimal outcomes for patients with unique needs. With the advent of personalized medicine, a new paradigm in healthcare, dentistry is poised to revolutionize the…
Read MoreIntroduction Periodontal diseases, including gingivitis and periodontitis, can lead to the destruction of these supporting structures, ultimately resulting in tooth loss if not adequately treated. Various biomaterials have been used so far for periodontal regeneration purposes. Recent advances in biomaterials and regenerative techniques have introduced nanografts as a promising approach to periodontal regeneration. This comprehensive…
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