What is a landmark study? A landmark study is a research investigation that significantly impacts a field of study by introducing novel concepts, providing groundbreaking findings, or validating important theories. These studies are often pivotal in shaping future research, influencing clinical practices, or altering theoretical frameworks. Following are the key characteristics of landmark studies: Innovative…
Read MoreIntroduction Ribonucleic acid (RNA) is a crucial molecule involved in various biological roles, primarily in coding, decoding, regulation, and expression of genes. Unlike DNA, which is double-stranded, RNA is typically single-stranded and comes in several forms, each serving different functions within the cell. Types of RNA Messenger RNA (mRNA): Carries genetic information from DNA to…
Read MoreIntroduction Genomics, the study of the entirety of an organism’s genes (the genome), and their interactions with each other and the environment, has become a cornerstone of modern medicine. With the completion of the Human Genome Project in 2003, a new era in medical science was ushered in, providing unprecedented insights into the genetic basis…
Read MoreIntroduction Arrestin beta-2 (ARRB2), one of the four members of the arrestin family, plays a pivotal role in cellular signaling, particularly in the regulation of G-protein-coupled receptors (GPCRs). Arrestins, including ARRB2, are versatile scaffold proteins that modulate various signaling pathways, influencing physiological and pathological processes. Arrestin beta-2 is a multi-domain protein consisting of approximately 410…
Read MoreIntroduction LIGHT protein (Lymphotoxin-beta receptor Interacting with G Protein-coupled Receptor), is a significant cytokine involved in immune regulation and inflammation. It plays a critical role in various physiological and pathological processes, particularly those related to immune responses and inflammation. Understanding LIGHT’s structure, function, and interactions is crucial for grasping its role in diseases, including periodontal…
Read MoreIntroduction Metabolomic analysis is a powerful tool that has gained significant attention in the study of various diseases, including periodontal disease. Periodontal disease, a chronic inflammatory condition affecting the supporting structures of the teeth, is linked to a complex interplay of microbial, host, and environmental factors. Understanding the metabolic changes associated with periodontal disease can…
Read MoreIntroduction Artificial intelligence (AI) has rapidly evolved from a concept of science fiction to a transformative force in various industries, including healthcare. Dentistry, particularly the fields of periodontics and implantology, has seen significant advancements due to the integration of AI technologies. These innovations have the potential to revolutionize diagnostic processes, treatment planning, and patient care,…
Read MoreIntroduction Botulinum toxin, commonly known as Botox, is widely recognized for its cosmetic applications in reducing facial wrinkles. However, its utility extends far beyond aesthetic enhancements. In dentistry, Botox is gaining traction for its therapeutic benefits in treating a variety of orofacial conditions. Botox is derived from the bacterium Clostridium botulinum. The Hall strain of…
Read MoreIntroduction Periodontics is a branch of dentistry that focuses on the structures supporting the teeth, including the gums and bone. Traditionally, periodontal treatment has followed a one-size-fits-all approach, often leading to suboptimal outcomes for patients with unique needs. With the advent of personalized medicine, a new paradigm in healthcare, dentistry is poised to revolutionize the…
Read MoreIntroduction Periodontal diseases, including gingivitis and periodontitis, can lead to the destruction of these supporting structures, ultimately resulting in tooth loss if not adequately treated. Various biomaterials have been used so far for periodontal regeneration purposes. Recent advances in biomaterials and regenerative techniques have introduced nanografts as a promising approach to periodontal regeneration. This comprehensive…
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