Thesis, antithesis and synthesis in periodontal and systemic interlink

Introduction The thesis, antithesis, and synthesis framework, derived from Hegelian dialectics, can be a useful way to conceptualize the interrelationship between two or more variables. Hegelian dialectics is a philosophical framework developed by the German philosopher Georg Wilhelm Friedrich Hegel (1770–1831) (reference available in book). It is a method of logical progression that explores the…

Read More

Use of animal models in biomedical research in periodontics

Introduction Animal models play a crucial role in biomedical research by providing insights into the complex biological processes that occur in humans. In fields like periodontics, where research focuses on understanding disease mechanisms, tissue regeneration, and the efficacy of treatments, animal models are invaluable. They bridge the gap between in vitro studies (experiments in controlled…

Read More

Critical analysis of various plaque hypotheses and future directions

Introduction Dental plaque is a complex biofilm composed of bacteria, their by-products, host cells, and organic molecules that form on tooth surfaces. It is a primary etiological factor in the development of periodontal diseases, which include gingivitis and periodontitis. In periodontal disease, dental plaque accumulation triggers an inflammatory response in the gums. Initially, this response…

Read More

Principles of prescription writing

Introduction Prescription writing is a core responsibility of healthcare providers. It involves the issuance of instructions regarding the administration of drugs to treat illnesses or conditions. Despite advances in digital technology, prescriptions remain vital to patient care, acting as a bridge between diagnosis and treatment. The art of writing prescriptions lies in striking the balance…

Read More

Genetic Polymorphism

Introduction Genetic Polymorphism refers to the occurrence of two or more distinct alleles at a particular gene locus within a population’s genetic makeup, where the least common allele has a frequency of at least 1% in the population. These variations can exist in the form of single nucleotide differences, insertions, deletions, or larger structural changes…

Read More

Landmark studies in periodontics and implantology

What is a landmark study? A landmark study is a research investigation that significantly impacts a field of study by introducing novel concepts, providing groundbreaking findings, or validating important theories. These studies are often pivotal in shaping future research, influencing clinical practices, or altering theoretical frameworks. Following are the key characteristics of landmark studies: Innovative…

Read More

Peri-implantitis and its management

Introduction Peri-implantitis is a significant and increasingly recognized complication in the field of implant dentistry. As the global prevalence of dental implants rises, so does the occurrence of peri-implant diseases, with peri-implantitis being the most severe form. Characterized by inflammation in the peri-implant tissues and progressive bone loss around the implant, peri-implantitis poses a serious…

Read More

RNA Interference: Mechanisms, Applications, and Therapeutic Potential

Introduction Ribonucleic acid (RNA) is a crucial molecule involved in various biological roles, primarily in coding, decoding, regulation, and expression of genes. Unlike DNA, which is double-stranded, RNA is typically single-stranded and comes in several forms, each serving different functions within the cell. Types of RNA Messenger RNA (mRNA): Carries genetic information from DNA to…

Read More