Multiple Choice Question Test - XI (Basic Periodontology).

This is a self assessment test consisting of ten questions. Click evaluate to get result.

1. Which of the following is not true about Chronic granulomatous disease (CGD),

It is a group of diseases characterized by the inability of the phagocyte to reduce oxygen. Because the host phagocytes are unable to mount a normal respiratory burst (ie., reduce oxygen) they have difficulty controlling organisms which do not release reduced oxygen metabolites themselves. Apparently, catalase negative bacteria release enough hydrogen peroxide to assist neutrophils perform oxidative killing. The inability to rapidly dispatch bacteria which gain access to the connective tissues leads to the formation of granulomas by the chronic immune cells. CGD is not strongly associated with periodontitis, suggesting that phagocyte defense against facultative bacteria invading “normoxic” connective tissue is less important than defense against anaerobic bacteria in hypoxic gingival crevice.

Defects of the NADPH oxidase system so that normal respiratory burst and free radical production is diminished.
Diagnosed by recurrent infections by catalase +ve bacteria.
Bacteria gain access to connective tissues leading to formation of granulomas by chronic immune cells.
CGD is strongly associated with periodontitis.
Correct Answer - option 4

2. Prothrombin is,

α- Globulins: 

These are found in two forms, α1 and α 2.

Mol wt. 41KDa to 200KDa.

Ph- 5.1

α 1 consists of 2 fractions. It combines with billirubin. It is carrier for steroids, lipids and glycoproteins.

α 2 consist of α 2 microglobulins, mucoproteins & ceruloplasmin.

β- Globulins:  Mol wt. 90,000- 1,300,000Da. pH -5.6. it is of following types

β lipoprotein – which helps in carriage of lipids, steroids and caroteine.

Globulin- which help in carriage of iron i:e transferin.

Prothrombin is a beta globulin.

γ- Globulin:

 Mol wt. 150,000Da to 190,000Da

 ph is 6

 These are antibodies.

α- Globulin.
β- Globulin.
γ- Globulin.
None of above.
Correct Answer - option 2

3. Which of the following is most accurate about types of collagen and the tissues in which they are found,

The basic structural collagen unit is tropocollagen. It consists of 3 linear polypeptide chains (α 1,2,3) of 1,000 amino acid residues that intertwine forming a triple helix 300 nm long and 15 A wide. Type I predominates and is found in all CT, especially skin and bone; type II is found mainly in cartilage. Type III is present primarily in smooth muscle, especially blood vessels. Type IV is found in basement membranes. Glycine accounts for onethird of all amino acids in collagen. Collagen is also rich in projine, hydroxyproline, and hydroxylysine.

Type I collagen- All Connective Tissues, Type II collagen- Mainly in Smooth muscle, Type III collagen- Mainly in cartilage, Type IV collagen- Basement membrane.
Type I collagen- All Connective Tissues, Type II collagen- Mainly in cartilage, Type III collagen- Mainly in smooth muscle, Type IV collagen- Basement membrane.
Type I collagen- All Connective Tissues, Type II collagen- Basement membrane, Type III collagen- Mainly in smooth muscle, Type IV collagen- Mainly in cartilage.
Type I collagen- All Connective Tissues, Type II collagen- Mainly in cartilage, Type III collagen- Basement membrane, Type IV collagen- Mainly in smooth muscle.
Correct Answer - option 2

4. CD-4 is a

CD1 = an MHC-like molecule that presents lipid molecules.

CD3 = the signaling component of the T-cell receptor (TCR) complex.

CD4 = a co-receptor for the TCR that is found on T-helper cells; also a receptor used by HIV to  

         enter T cells.

CD8 = a co-receptor for the TCR that is found on cytotoxic T cells.

CD31 = PECAM-1, a cell adhesion molecule on platelets and endothelial cells.

CD35 = Complement receptor 1 (C3b/C4b receptor).

CD36 = Platelet glycoprotein IV or IIIb (GP IV / GP IIIb).

CD56 = a marker for natural killer cells and some T-lymphocytes.

CD71 = Transferrin receptor, mediates cellular uptake of iron.

CD117 = c-kit, the receptor for Stem Cell Factor, a glycoprotein that regulates cellular

            differentiation, particularly in hematopoiesis.

CD120 = a receptor for Tumour Necrosis Factor, an inflammatory cytokine.

CD142 = Tissue factor, a major initiator of blood-clotting.

CD143 = Angiotensin-converting enzyme.

CD144 = VE-Cadherin, a calcium-dependent adhesion molecule at intercellular junctions, found only

             in the vascular endothelium.

CD202a = Tie2, the receptor for angiopoietins, a family of angiogenic factors

A MHC-like molecule that presents lipid molecules.
The signaling component of the T-cell receptor (TCR) complex.
A co-receptor for the TCR that is found on T-helper cells; also a receptor used by HIV to enter T cells.
A co-receptor for the TCR that is found on cytotoxic T cells.
Correct Answer - option 3

5. The major MMPs in neutrophils are,

The major MMPs in neutrophils are MMP-8 (collagenase-2) and MMP-9 (gelatinase B). While MMP-

8 is able to potently to degrade interstitial collagens, MMP-9 is a gelatinolytic enzyme degrading several extracellular matrix proteins, including basement membrane (type IV) collagen. MMP-8 and -9 are the main collagen-degrading enzymes in GCF and saliva (77, 109), and they are believed to be mainly responsible for collagen degradation in inflamed tissue during gingivitis and adult periodontitis

Reference: Uitto V J et al.Proteolytic host cell enzymes in gingival crevice fluid. Periodontology 2000, Vol. 31, 2003, 77–104.

MMP-1 and MMP-2.
MMP-8 and MMP-9.
MMP-10 and MMP-11.
MMP-13 and MMP-14.
Correct Answer - option 2

6. Which of the following is not true about T. denticola,

T.denticolais an oral spirochetes normally cultivated in vitro under anaerobic conditions. However anaerobiosis is not an absolute requirements for the cultivation of this spirochetes. T.denticola is especially sensitive to oxygen. Although T.denticola lives predominantly in an anaerobic environment and it is capable of utilizing low levels of oxygen and protecting itself from oxygen radicals.

Reference: Loesche WJ. Oxygen sensitivity of various anaerobic bacteria. Appl Microbiol. 1969; 18: 723-7.

T.denticola is an oral spirochetes normally cultivated in vitro under anaerobic conditions.
Anaerobic environment is an absolute requirement for the cultivation of these spirochetes.
Major surface protein (MSP) have shown to posses the ability to bind a variety of matrix proteins and to bind host cells.
T.denticola has two periplasmic flagella (PF) at each end.
Correct Answer - option 2

7. Which of the following is not true about periodontal ligament,

The periodontal ligaments of primary teeth are wider than those found in permanent teeth.

Is a fibrous connective tissue, which occupies the periodontal space.
Located between the cementum & the periodontal surfaces of the alveolar bone.
The width of periodontal ligament is not uniform it ranges from 0.15-0.21mm.
The periodontal ligaments of primary teeth are narrower than those found in permanent teeth.
Correct Answer - option 4

8. Which of the following is a multi-colony stimulating factor,

Colony-stimulating factors (CSF) were named for their ability to induce the development of distinct cell lineages. Erythropoietin is a cytokine produced by the kidney that stimulates proliferation and differentiation of erythroid cells into erythrocytes. Macrophage-CSF (M-CSF) and granulocyte-CSF (G-CSF) more specifically promote the differentiation of macrophages and granulocytes respectively. IL-3 is a CSF known as multi-CSF. It stimulates the formation of all lymphocytes.

Erythropoietin.
Macrophage-CSF (M-CSF).
Granulocyte-CSF (G-CSF).
IL-3.
Correct Answer - option 4

9. LXA4 has all the following functions except,

Lipoxin A4 (LXA4), a derivative of arachidonic acid formed by lipoxygenases (LO), has endogenous

anti-inflammation and resolution properties. LXA4 was described to block IL-1β and TNF-α release in a time- and concentration-dependent manner, and consequently to inhibit leukocyte trafficking.

Reference: G.P. Garlet. Destructive and Protective Roles of Cytokines in Periodontitis: A

Re-appraisal from Host Defense and Tissue Destruction Viewpoints. J Dent Res 89(12):1349-1363, 2010

It block IL-1β and TNF-α release in a time- and concentration-dependent manner.
It Inhibits leukocyte trafficking.
It significantly attenuates inflammatory reaction.
All of above.
Correct Answer - option 4

10. Which of the following is known as Rathbun disease,

Synonyms for Hypophospahatasia are

  • Phosphoethanolamineurea
  • Rathbun disease
  • HOPS
Osteogenesis imperfecta.
Achondrogenesis.
Hypophospahatasia.
Dentinogenesis imperfecta.
Correct Answer - option 3



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